Chronic City by Jonathan Lethem (Random House Audio, read by Mark Deakins)
That's right, audio book. Which seems appropriate. Because when listening to Mr. Deakins soar, sink, and hiccough his way through his recitation of the labyrinthine, pulpy narrative that Lethem teases out of the raw materials of millennial Manhattan, my mind's eye thought more than once, "Would that Orson Welles and his Mercury Theater of the Air had their shot at this one!" The clotted, spooky story, full of diabolical artistes, creepy mayoral aides-de-camp, monstrous giants, and cancerous space girls, all orbiting around a consumptive genius, was begging for the same crew that put together "The Shadow Knows," The War of the Worlds, and Citizen Kane.